Chutko L S, Yakovenko E A, Surushkina S Yu, Kryukova E M, Palaieva S V
Bekhtereva Human Brain Research Institute, Russian Academy of Sciences, St. Petersburg, Russia.
Orenburg Regional Clinical Psychiatric Hospital #1, Orenburg, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2017;117(9):71-75. doi: 10.17116/jnevro20171179171-75.
To evaluate clinical and neurophysiological changes in children with different variants of autism spectrum disorders during treatment with cerebrolysin.
Forty-three children with autism spectrum disorders, aged 4-6 years, were included in the study. To assess the degree of autism, the quantitative scale of assessing the severity of child autism CARS ('Childhood Autism Rating Scale') was used. A comparative analysis of the clinical picture of disease and data of the electroencephalographic examination in endogenous and exogenous (organic) variant of autism was made.
In children with exogenous (organic) autism, the lower scores of autistic symptom on the CARS and a greater degree of functional immaturity of the cerebral cortex, according to electroencephalographic results, were found compared to children with endogenous autism. After treatment with cerebrolysin, 27 children (62.8%) showed signs of improvement. An improvement was noted in 13 children in with endogenous autism (56.5%) and in 14 children with organic autism (70.0%). CARS scores showed a more pronounced decrease in this indicator in a subgroup of children with organic autism.
评估患有不同类型自闭症谱系障碍的儿童在使用脑蛋白水解物治疗期间的临床和神经生理学变化。
本研究纳入了43名4至6岁的自闭症谱系障碍儿童。为评估自闭症程度，使用了评估儿童自闭症严重程度的定量量表——儿童自闭症评定量表（CARS）。对内源性和外源性（器质性）自闭症的疾病临床表现和脑电图检查数据进行了对比分析。
根据脑电图结果，与内源性自闭症儿童相比，外源性（器质性）自闭症儿童在CARS上的自闭症症状得分更低，大脑皮层功能不成熟程度更高。使用脑蛋白水解物治疗后，27名儿童（62.8%）显示出改善迹象。内源性自闭症儿童中有13名（56.5%）出现改善，器质性自闭症儿童中有14名（70.0%）出现改善。CARS评分显示，在器质性自闭症儿童亚组中该指标下降更为明显。
