Prod'hom G, Bille J
Institut de microbiologie, Département de pathologie et de médecine de laboratoire CHUV, 1011 Lausanne.
Rev Med Suisse. 2008 Apr 9;4(152):908-13.
POCT have a great potential in ambulatory infectious diseases diagnosis, due to their impact on antibiotic administration and on communicable diseases prevention. Some are in use for long (S. pyogenes antigen, HIV antibodies) or short time (S. pneumoniae antigen, P. falciparum). The additional major indications will be community-acquired lower respiratory tract infections, infectious diarrhoea in children (rotavirus, enterotoxigenic E. coli), and hopefully sexually transmitted infections. Easy to use, these tests based on antigen-antibody reaction allow a rapid diagnosis in less than one hour; the new generation of POCT relying on nucleic acid detection are just introduced in practice (detection of GBS in pregnant women, carriage of MRSA), and will be extended to many pathogens.
即时检验(POCT)在门诊传染病诊断方面具有巨大潜力,因为其对抗生素使用及传染病预防有影响。有些已长期使用(化脓性链球菌抗原、HIV抗体)或短期使用(肺炎链球菌抗原、恶性疟原虫)。其他主要适应症将是社区获得性下呼吸道感染、儿童感染性腹泻(轮状病毒、产肠毒素大肠杆菌),有望还包括性传播感染。这些基于抗原 - 抗体反应的检测易于使用,能在不到一小时内快速诊断;新一代基于核酸检测的即时检验刚刚投入实际应用(检测孕妇中的B族链球菌、耐甲氧西林金黄色葡萄球菌携带情况),并将扩展至多种病原体检测。