大鼠脑中的另类翻译起始产生对钠通透的K2P2.1钾通道。
Alternative translation initiation in rat brain yields K2P2.1 potassium channels permeable to sodium.
作者信息
Thomas Dierk, Plant Leigh D, Wilkens Christina M, McCrossan Zoe A, Goldstein Steve A N
机构信息
Department of Pediatrics and Institute for Molecular Pediatric Sciences, Pritzker School of Medicine, University of Chicago, 5721 South Maryland Avenue, Chicago, IL 60637, USA.
出版信息
Neuron. 2008 Jun 26;58(6):859-70. doi: 10.1016/j.neuron.2008.04.016.
K(2P) channels mediate potassium background currents essential to central nervous system function, controlling excitability by stabilizing membrane potential below firing threshold and expediting repolarization. Here, we show that alternative translation initiation (ATI) regulates function of K(2P)2.1 (TREK-1) via an unexpected strategy. Full-length K(2P)2.1 and an isoform lacking the first 56 residues of the intracellular N terminus (K(2P)2.1Delta1-56) are produced differentially in a regional and developmental manner in the rat central nervous system, the latter passing sodium under physiological conditions leading to membrane depolarization. Control of ion selectivity via ATI is proposed to be a natural, epigenetic mechanism for spatial and temporal regulation of neuronal excitability.
K(2P)通道介导对中枢神经系统功能至关重要的钾离子背景电流，通过将膜电位稳定在放电阈值以下并加速复极化来控制兴奋性。在此，我们表明，可变翻译起始（ATI）通过一种意想不到的策略调节K(2P)2.1（TREK-1）的功能。全长K(2P)2.1和一种缺少细胞内N端前56个残基的异构体（K(2P)2.1Delta1-56）在大鼠中枢神经系统中以区域和发育方式差异产生，后者在生理条件下允许钠离子通过，导致膜去极化。通过ATI对离子选择性的控制被认为是一种对神经元兴奋性进行空间和时间调节的天然表观遗传机制。
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