Meyenberger C, Altorfer J, Münch R, Müller A, Ammann R
Departement für Innere Medizin, Universitätsspital Zürich.
Schweiz Med Wochenschr. 1991 Jun 8;121(23):877-80.
A 22-year-old woman with hypertrophic protein-losing gastropathy (Ménétrier's disease) is described. During treatment with ranitidine (Zantic) and pirenzepine (Gastrozepin) the gastric mucosa and protein loss were normalized within 4 years. Clinical and histological remission has now been observed for 5 and 3 years respectively. In a 57-year-old woman with hypertrophic gastropathy, 8 months' treatment with ranitidine and pirenzepine was associated with decrease in protein loss and improvement of the histological appearance of the gastric mucosa after one year. Long-term treatment of hypertrophic gastropathy with ranitidine and/or pirenzepine should, therefore, be considered in such cases instead of gastrectomy.
本文描述了一名患有肥厚性蛋白丢失性胃病（梅内特里耶病）的22岁女性。在使用雷尼替丁（善胃得）和哌仑西平（胃仙-U）治疗期间，胃黏膜和蛋白丢失在4年内恢复正常。目前分别观察到临床和组织学缓解已达5年和3年。在一名患有肥厚性胃病的57岁女性中，雷尼替丁和哌仑西平治疗8个月后，一年后蛋白丢失减少，胃黏膜组织学外观改善。因此，对于此类病例，应考虑用雷尼替丁和/或哌仑西平长期治疗肥厚性胃病，而非胃切除术。
