Wu A C, Fuhlbrigge A L
Department of Ambulatory Care and Prevention, Harvard Medical School and Children's Hospital, Boston, Massachusetts, USA.
Clin Pharmacol Ther. 2008 Aug;84(2):272-4. doi: 10.1038/clpt.2008.127. Epub 2008 Jun 25.
Ever since the sequencing of the human genome was completed, prediction of treatment response in terms of genetic variation has been seen as an important and achievable goal. Pharmacogenetics is the study of how genetic differences affect variation in response to medication. One potential goal of pharmacogenetics is to be able to deliver "personalized medicine" by making management decisions that optimize patient health outcomes based on a patient's genetic makeup. Pharmacogenetic tests have the potential to (i) predict intended response, the goal outcome of the medication; (ii) predict unintended response to the medication, such as adverse events; (iii) titrate medication dose; and (iv) inform the development of novel therapeutics.
自人类基因组测序完成以来，根据基因变异预测治疗反应一直被视为一个重要且可实现的目标。药物遗传学是研究基因差异如何影响药物反应差异的学科。药物遗传学的一个潜在目标是通过基于患者基因构成做出优化患者健康结果的管理决策，从而实现“个性化医疗”。药物遗传学检测有可能：（i）预测预期反应，即药物的目标疗效；（ii）预测对药物的非预期反应，如不良事件；（iii）调整药物剂量；以及（iv）为新型疗法的研发提供信息。
