da Silva Lourinalda Luiza Dantas, Nascimento Márcia Silva, Cavalheiro Alberto José, Silva Dulce Helena Siqueira, Castro-Gamboa Ian, Furlan Maysa, Bolzani Vanderlan da Silva
Departamento de Química, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, S/N 52171-900 Recife, PE, Brazil.
J Nat Prod. 2008 Jul;71(7):1291-3. doi: 10.1021/np800106x. Epub 2008 Jun 27.
As part of a continuing interest in exploring the chemistry of Brazilian medicinal plants, three new labdane diterpenoids, 6alpha-acetoxymanoyl oxide (1), 6alpha-malonyloxymanoyl oxide (2), and 6alpha-malonyloxy-n-butyl ester manoyl oxide (3), together with the known betulinic acid, lupeol, sitosterol, and stigmasterol, were isolated from the aerial parts of Stemodia foliosa. The structures of 1-3 were established on the basis of interpretation of spectroscopic data, including HRESIMS, and 1D and 2D NMR techniques. All compounds were tested against a bacteria panel consisting of Staphylococcus aureus, Bacillus cereus, B. subtilis, B. anthracis, Micrococcus luteus, Mycobacterium smegmatis, and M. phlei. Compound 2 showed moderate activity against these strains, with MIC values in the range 7-20 microg/mL.
作为对巴西药用植物化学研究持续兴趣的一部分，从多叶地皮消的地上部分分离出了三种新的半日花烷二萜类化合物，即6α-乙酰氧基曼诺醇氧化物（1）、6α-丙二酰氧基曼诺醇氧化物（2）和6α-丙二酰氧基正丁酯曼诺醇氧化物（3），以及已知的桦木酸、羽扇豆醇、甾醇和豆甾醇。通过对包括高分辨电喷雾电离质谱（HRESIMS）以及一维和二维核磁共振（NMR）技术在内的光谱数据进行解析，确定了化合物1 - 3的结构。所有化合物均针对一组细菌进行了测试，这些细菌包括金黄色葡萄球菌、蜡样芽孢杆菌、枯草芽孢杆菌、炭疽芽孢杆菌、藤黄微球菌、耻垢分枝杆菌和草分枝杆菌。化合物2对这些菌株表现出中等活性，其最低抑菌浓度（MIC）值在7 - 20微克/毫升范围内。
Zotero 插件