Rijo Patricia, Simões Maria Fátima, Duarte Aida, Rodríguez Benjamín
Faculdade de Farmácia da Universidade de Lisboa, iMed. UL, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal.
Instituto de Química Orgánica, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain.
Phytochemistry. 2009 Jun;70(9):1161-1165. doi: 10.1016/j.phytochem.2009.06.008. Epub 2009 Jul 22.
Four acyloxy-isopimarane derivatives along with two known isopimarane diterpenoids, the flavone cirsimaritin and the sterols beta-sitosterol and stigmasterol were isolated from the aerial parts of Aeollanthus rydingianus. The structures of the compounds were established on the basis of spectroscopic analysis and chemical evidence. The isolated substances were screened for antimicrobial activity against Gram-positive and Gram-negative bacteria and a yeast strain. 19-Acetoxy-7,15-isopimaradien-3beta-ol and 7,15-isopimaradien-19-ol showed minimum inhibitory concentration (MIC) values of 3.90-15.62 microg/ml for Staphylococcus aureus and of 7.81microg/ml for Enterococcus hirae.
从赖丁香紫苏的地上部分分离出四种酰氧基异海松烷衍生物以及两种已知的异海松烷二萜、黄酮类化合物 cirsimaritin 和甾醇类化合物β-谷甾醇和豆甾醇。这些化合物的结构是基于光谱分析和化学证据确定的。对分离出的物质进行了针对革兰氏阳性菌、革兰氏阴性菌和一种酵母菌株的抗菌活性筛选。19-乙酰氧基-7,15-异海松二烯-3β-醇和 7,15-异海松二烯-19-醇对金黄色葡萄球菌的最低抑菌浓度（MIC）值为 3.90 - 15.62 μg/ml，对希氏肠球菌的 MIC 值为 7.8 μg/ml。
