一种从丛生鼠尾草根部提取的新型抗菌二萜。

A new antibacterial diterpene from the roots of Salvia caespitosa.

作者信息

Ulubelen A, Oksüz S, Topcu G, Gören A C, Bozok-Johansson C, Celik C, Kökdil G, Voelter W

机构信息

Department of Chemistry, Faculty of Pharmacy, University of Istanbul, Turkey.

出版信息

Nat Prod Lett. 2001;15(5):307-14. doi: 10.1080/10575630108041297.

DOI:10.1080/10575630108041297

PMID:11841114

Abstract

From the roots of Saliva caespitosa Montbret and Aucher ex. Bentham a new diterpene 6beta-hydroxyisopimaric acid (1) has been isolated together with four known diterpenes, one new triterpenoid, 3-acetylvergatic acid (2), as well as five known triterpenoids, two steroids and a flavone. The structures of the compounds were established by spectroscopic analyses. The isolated compounds were tested against standard bacterial strains. Only the new diterpene, 6beta-hydroxyisopimaric acid has strong activity (MIC 9 microg/ml) against S. aureus and (MIC 18 microg/ml) against S. epidermidis as well as against B. subtilis (MIC 9 microg/ml).

摘要

从丛生唾液草（Saliva caespitosa Montbret and Aucher ex. Bentham）的根部分离出一种新的二萜类化合物6β-羟基异海松酸（1），同时还分离出四种已知的二萜类化合物、一种新的三萜类化合物3-乙酰维加酸（2），以及五种已知的三萜类化合物、两种甾体和一种黄酮。通过光谱分析确定了这些化合物的结构。对分离出的化合物针对标准细菌菌株进行了测试。只有新的二萜类化合物6β-羟基异海松酸对金黄色葡萄球菌具有较强活性（最低抑菌浓度为9微克/毫升），对表皮葡萄球菌（最低抑菌浓度为18微克/毫升）以及枯草芽孢杆菌（最低抑菌浓度为9微克/毫升）也有活性。