el Bahri L, Ben Romdane S
Service de Pharmacie-Toxicologie, Ecole National de Medecine Veterinaire, Sidi Thabet, Tunisia.
Vet Hum Toxicol. 1991 Jun;33(3):259-64.
Arsenic is an important heavy metal intoxicant to livestock. Arsenical pesticides present significant hazards to animal health. The toxicity of arsenic varies with several factors--its chemical form, oxidation states, solubility. The phenylarsonic compounds are the least toxic and are used as feed additives in swine and poultry rations. However, roxarsone has a higher absolute toxicity than arsanilic acid. The mechanism of action is related to its reaction with sulfhydryl groups values to enzyme function and to its ability to uncouple oxydative phosphorylation. Most animals excrete arsenic quite readily. Toxicoses caused by inorganic and aliphatic organic arsenicals result in a different clinical syndrome than that from the phenylarsonic compounds. Arsenic poisoning may be confused with other types of intoxication. The specific antidote for inorganic arsenical poisoning is dimercaprol (BAL).
砷是对家畜重要的重金属毒物。含砷农药对动物健康存在重大危害。砷的毒性因多种因素而异——其化学形式、氧化态、溶解度。苯基砷化合物毒性最小，用作猪和家禽日粮的饲料添加剂。然而，洛克沙胂的绝对毒性高于对氨基苯胂酸。其作用机制与其与巯基基团反应影响酶功能以及解偶联氧化磷酸化的能力有关。大多数动物很容易排出砷。无机和脂肪族有机砷引起的中毒导致的临床综合征与苯基砷化合物不同。砷中毒可能与其他类型的中毒相混淆。无机砷中毒的特效解毒剂是二巯丙醇（BAL）。
