Lalonde R, Strazielle C
Centre Hospitalier de l'Université de Montréal/St-Luc, Unité de Recherche en Sciences Neurologiques, 1058 St-Denis St., Montréal, Que. H2X3J4, Canada.
Neurobiol Learn Mem. 2008 Sep;90(2):472-4. doi: 10.1016/j.nlm.2008.05.004. Epub 2008 Jun 25.
Rora(sg) mutants with mild cerebellar granule cell degeneration were compared to Grid2(ho) mutants with more severe granule cell degeneration as well as Purkinle cell atrophy for left-right and dark-light discrimination learning tasks in a water-filled T-maze. The acquisition rate of both cerebellar mutants was slowed down during light-dark but not left-right discrimination learning. However, the mutants were impaired in reversal training in both tasks. In contrast, neither mutant differed from controls in passive avoidance learning. These results indicate that mice with cerebellar damage are affected in some instrumental learning tasks and have perseverative tendencies.
将患有轻度小脑颗粒细胞变性的Rora（sg）突变体与患有更严重颗粒细胞变性以及浦肯野细胞萎缩的Grid2（ho）突变体进行比较，以研究它们在充满水的T型迷宫中进行左右辨别和明暗辨别学习任务的情况。在明暗辨别学习过程中，两种小脑突变体的习得率均减慢，但在左右辨别学习中则不然。然而，在两项任务的逆向训练中，突变体均表现受损。相比之下，在被动回避学习中，两种突变体与对照组均无差异。这些结果表明，小脑受损的小鼠在某些工具性学习任务中受到影响，并具有固执倾向。
