Belzung C, Chapillon P, Lalonde R
Université de Tours, EA Psychobiologie des émotions, Tours, France.
Behav Genet. 2001 Mar;31(2):151-5. doi: 10.1023/a:1010269126295.
The Lurcher mutation is characterized by degeneration of the cerebellar cortex and cerebellar ataxia. The mutants were compared to littermate controls of the same background strain in three spatial tasks: 1) left-right discrimination in a water-filled T-maze, a reference memory task requiring a win-stay strategy; 2) the radial arm maze, a working memory task requiring a win-shift strategy; 3) object localization, a reference memory task requiring the use of cognitive mapping. Lurcher mutants were impaired in the object localization and radial arm maze tasks but not in the left-right discrimination task. These results indicate that trial-independent tasks and reference memory tasks using cognitive mapping may be particularly vulnerable to cerebellar degeneration.
“蹒跚者”突变的特征是小脑皮质退化和小脑共济失调。在三项空间任务中，将这些突变体与相同背景品系的同窝对照进行比较：1）在充满水的T型迷宫中进行左右辨别，这是一项需要赢则停留策略的参考记忆任务；2）放射状臂迷宫，这是一项需要赢则转换策略的工作记忆任务；3）物体定位，这是一项需要使用认知地图的参考记忆任务。“蹒跚者”突变体在物体定位和放射状臂迷宫任务中受损，但在左右辨别任务中未受损。这些结果表明，使用认知地图的与试验无关的任务和参考记忆任务可能特别容易受到小脑退化的影响。
