Reuser Mieke, Bonneux Luc, Willekens Frans
Netherlands Interdisciplinary Demographic Institute, P.O. Box 11650, 2502 AR, The Hague, The Netherlands.
Eur J Epidemiol. 2008;23(9):601-7. doi: 10.1007/s10654-008-9269-8. Epub 2008 Jun 27.
The evidence of effect of overweight and obesity on mortality at middle and old age is conflicting. The increased relative risk of cardiovascular disease and diabetes for overweight and obese individuals compared to normal weight is well documented, but the absolute risk of cardiovascular death has decreased spectacularly since the 1980s. We estimate the burden of mortality of obesity among middle and old aged adults in the Health and Retirement Survey (HRS), a US prospective longitudinal study. We calculate univariate and multivariate age-specific probabilities and proportional hazard ratios of death in relation to self-reported body mass index (BMI), smoking and education. The life table translates age specific adjusted event rates in survival times, dependent on risk factor distributions (smoking, levels of education and self reported BMI). 95% confidence intervals are calculated by bootstrapping. The highest life expectancy at age 55 was found in overweight (BMI 25-29.9), highly educated non smokers: 30.7 (29.5-31.9) years (men) and 33.2 (32.1-34.3) (women), slightly higher than a BMI 23-24.9 in both sexes. Smoking decreased the population life expectancy with 3.5 (2.7-4.4) years (men) and 1.8 (1.0-2.5) years (women). Less than optimal education cost men and women respectively 2.8 (2.1-3.6) and 2.6 (1.6-3.6) years. Obesity and low normal weight decreased population life expectancy respectively by 0.8 (0.2-1.3) and 0.8 (0.0-1.5) years for men and women in a contemporary, US population. The burden of mortality of obesity is limited, compared to smoking and low education.
超重和肥胖对中老年死亡率的影响证据存在矛盾。与正常体重者相比,超重和肥胖个体患心血管疾病和糖尿病的相对风险增加,这一点有充分记录,但自20世纪80年代以来,心血管死亡的绝对风险已大幅下降。我们在美国一项前瞻性纵向研究“健康与退休调查”(HRS)中估算了中老年成年人肥胖的死亡负担。我们计算了与自我报告的体重指数(BMI)、吸烟和教育程度相关的单变量和多变量特定年龄死亡概率及比例风险比。生命表根据危险因素分布(吸烟、教育水平和自我报告的BMI)将特定年龄调整后的事件发生率转化为生存时间。通过自助法计算95%置信区间。在超重(BMI 25 - 29.9)、受过高等教育的非吸烟者中,55岁时的预期寿命最高:男性为30.7(29.5 - 31.9)年,女性为33.2(32.1 - 34.3)年,略高于两性BMI为23 - 24.9的情况。吸烟使男性总体预期寿命减少3.5(2.7 - 4.4)年,女性减少1.8(1.0 - 2.5)年。教育程度欠佳分别使男性和女性的预期寿命减少2.8(2.1 - 3.6)年和2.6(1.6 - 3.6)年。在当代美国人群中,肥胖和低正常体重分别使男性和女性的总体预期寿命减少0.8(0.2 - 1.