Usui Yoshihiko, Goto Hiroshi
Department of Ophthalmology, Tokyo Medical University Hospital, Tokyo, Japan.
Semin Ophthalmol. 2008 Jul-Aug;23(4):275-83. doi: 10.1080/08820530802111325.
Acute retinal necrosis (ARN) syndrome, also known as Kirisawa's uveitis, is one of the most serious ocular diseases, and is characterized by a combination of peripheral, confluent, necrotizing retinitis, retinal arteritis, and intraocular inflammation. ARN syndrome is caused by the herpesvirus family, including herpes simplex virus (HSV) and varicella-zoster virus (VZV). The diagnosis of ARN syndrome is fundamentally based on clinical appearance and the demonstration of viral infection. Recently, polymerase chain reaction techniques permit detection of very small amounts of viral DNA in intraocular specimens. This knowledge can help in both the diagnosis and design of therapeutic strategy for ARN syndrome. Here we review the clinical presentation and the current advances in the diagnosis of ARN syndrome.
急性视网膜坏死（ARN）综合征，又称桐泽型葡萄膜炎，是最严重的眼部疾病之一，其特征为周边性、融合性、坏死性视网膜炎、视网膜动脉炎和眼内炎症并存。ARN综合征由疱疹病毒科引起，包括单纯疱疹病毒（HSV）和水痘 - 带状疱疹病毒（VZV）。ARN综合征的诊断基本上基于临床表现和病毒感染的证实。最近，聚合酶链反应技术能够检测眼内标本中极少量的病毒DNA。这一知识有助于ARN综合征的诊断和治疗策略的设计。在此，我们综述ARN综合征的临床表现及诊断方面的当前进展。
