带状疱疹性角膜炎和结膜炎患者的双侧图形视网膜电图异常
Bilateral Pattern Electroretinogram Abnormalities in Patients with Herpes Zoster Keratitis and Conjunctivitis.
作者信息
Li Jingyi, Wang Yuexin, Xie Xin, Zeng Weizhen, Li Shiying, Agrawal Rupesh, Feng Yun
机构信息
Department of Ophthalmology, Peking University Third Hospital, No. 49, North Garden Street, Haidian District, Beijing, China.
Department of Ophthalmology, Xiang'an Hospital of Xiamen University, No. 2000, Xiang'an East Road, Xiang'an District, Xiamen, Fujian, China.
出版信息
Ophthalmol Ther. 2024 Jun;13(6):1589-1599. doi: 10.1007/s40123-024-00928-9. Epub 2024 Apr 8.
INTRODUCTION
Herpes zoster ophthalmicus (HZO) results from the reactivation of varicella zoster virus (VZV) in the ophthalmic branch of the trigeminal nerve. The inflammation caused by VZV involves multiple tissues in the eyes. Our goal is to evaluate pattern electroretinogram (PERG) changes and their relationship with corneal sub-basal nerve changes in patients with HZO.
METHODS
Twenty-two patients with herpes zoster keratitis or conjunctivitis and 20 healthy volunteers were recruited for this cross-sectional study. A PERG test was performed on both eyes of HZO patients and one eye of the healthy controls. In vivo confocal microscopy (IVCM) was also performed on both eyes of the HZO patients to detect corneal nerve damage.
RESULTS
Our results showed changes in the PERG parameters in both eyes of HZO patients compared to the healthy controls. Affected eyes showed delayed N95 peak time and decreased P50 and N95 amplitude compared to the unaffected eyes (p < 0.05, respectively). Both affected and unaffected eyes in HZO patients showed delayed P50 peak time and decreased N95 amplitude (p < 0.05, respectively) compared to controls. In HZO patients, no significant differences in each PERG parameter were found between eyes with and without corneal lesions or between eyes with and without increased Langham's cells in the corneal epithelial sub-basal layer. The IVCM images showed decreased total nerve length and number at the sub-basal layer of the epithelial cornea in affected eyes compared to unaffected eyes (p < 0.05). No significant correlation was found between total nerve length and PERG changes.
CONCLUSIONS
Our results showed that VZV-affected eyes without central cornea involvement displayed reduced N95 amplitude and prolonged P50 peak time in bilateral eyes compared to the healthy controls. Larger studies are needed to further explore the effect of HZO on the electrophysiological response of the eye and the posterior segment.
引言
眼部带状疱疹（HZO）是由水痘-带状疱疹病毒（VZV）在三叉神经眼支中重新激活引起的。VZV引发的炎症累及眼部多个组织。我们的目标是评估眼部带状疱疹患者的图形视网膜电图（PERG）变化及其与角膜基底膜下神经变化的关系。
方法
本横断面研究招募了22例带状疱疹性角膜炎或结膜炎患者和20名健康志愿者。对HZO患者的双眼和健康对照者的一只眼睛进行了PERG测试。还对HZO患者的双眼进行了共聚焦显微镜检查（IVCM）以检测角膜神经损伤。
结果
我们的结果显示，与健康对照相比，HZO患者双眼的PERG参数发生了变化。与未受影响的眼睛相比，受影响的眼睛N95峰时间延迟，P50和N95波幅降低（分别为p < 0.05）。与对照组相比，HZO患者受影响和未受影响的眼睛均显示P50峰时间延迟和N95波幅降低（分别为p < 0.05）。在HZO患者中，有角膜病变和无角膜病变的眼睛之间，以及角膜上皮基底膜下有和没有朗格汉斯细胞增多的眼睛之间，各PERG参数均无显著差异。IVCM图像显示，与未受影响的眼睛相比，受影响眼睛的角膜上皮基底膜下总神经长度和数量减少（p < 0.
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