Yoon Yeo-Hoon, Rha Ki-Sang, Koo Bon Seok, Park Jae Yong, Kim Yong Min, Park Yong Ho
Department of Otolaryngology-Head and Neck Surgery, Cancer Research Institute, Chungnam National University College of Medicine, Daejeon, Republic of Korea.
Otolaryngol Head Neck Surg. 2008 Jul;139(1):94-9. doi: 10.1016/j.otohns.2008.03.007.
The aim of this study was to investigate the preventive effect of halofuginone on posterior glottic stenosis (PGS) in an animal model.
A randomized, controlled animal study.
Sixteen male New Zealand White rabbits were used for this study. After the mucosa of posterior glottis was removed for producing PGS, the study group (eight rabbits) was given intraperitoneal halofuginone at 0.1 mg/kg/day for 4 weeks and saline was injected into peritoneum in the control group. At 4 weeks after injury, postsurgical changes of posterior glottis were evaluated by gross and histologic examination.
PGS was induced by the mucosal stripping of the posterior glottis. The halofuginone-treated group showed less scarring and granulation tissue formation. Also, the degree of synechia was significantly less than that of control group. Histologic analysis showed the decreased fibrosis in the halofuginone-treated group.
This study suggests that halofuginone can be helpful in preventing PGS after laryngeal injury.
本研究旨在探讨卤夫酮在动物模型中对声门后狭窄（PGS）的预防作用。
一项随机对照动物研究。
本研究使用了16只雄性新西兰白兔。在去除声门后黏膜以制造PGS后，研究组（8只兔子）腹腔注射卤夫酮，剂量为0.1mg/kg/天，持续4周，对照组腹腔注射生理盐水。损伤后4周，通过大体和组织学检查评估声门后的手术变化。
声门后黏膜剥脱诱导了PGS。卤夫酮治疗组的瘢痕形成和肉芽组织形成较少。此外，粘连程度明显低于对照组。组织学分析显示卤夫酮治疗组的纤维化程度降低。
本研究表明卤夫酮有助于预防喉损伤后的PGS。
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