常山酮对实验性诱导的声门下创伤继发纤维化形成的影响。
Effects of halofuginone on fibrosis formation secondary to experimentally induced subglottic trauma.
作者信息
Ertuğrul E Eylem, Cincik Hakan, Dogru Salim, Cekin Engin, Berber Ufuk, Gungor Atila, Poyrazoğlu I Ethem
机构信息
ENT Department, GATA Haydarpasa Educational Hospital, Kadikoy, Istanbul.
出版信息
Laryngoscope. 2007 Feb;117(2):299-302. doi: 10.1097/01.mlg.0000250593.19282.47.
OBJECTIVE
The aim of the study was to assess the antifibrotic effect of systemically applied halofuginone after subglottic injury.
MATERIALS AND METHODS
After standardized trauma to subglottic area, rats were divided into two groups: a study group that received treatment and a control group that did not. The rats were treated with 0.1 mg/kg/day intraperitoneal halofuginone injection for 30 days. The larynx specimens were examined histopathologically under light microscope for epithelization, inflammation, necrosis, and fibrosis.
RESULTS
The fibrosis indexes of the treated group were significantly less than those of the control group (P < .01).
CONCLUSIONS
Systemically applied halofuginone hydrobromide decreases fibrosis/scar tissue formation secondary to experimentally induced acute subglottic trauma.
目的
本研究旨在评估声门下损伤后全身应用常山酮的抗纤维化作用。
材料与方法
对声门下区域进行标准化创伤后，将大鼠分为两组：接受治疗的研究组和未接受治疗的对照组。大鼠接受腹腔注射0.1mg/kg/天的常山酮，持续30天。对喉部标本进行组织病理学检查，在光学显微镜下观察上皮化、炎症、坏死和纤维化情况。
结果
治疗组的纤维化指数显著低于对照组（P <.01）。
结论
全身应用氢溴酸常山酮可减少实验性诱导的急性声门下创伤继发的纤维化/瘢痕组织形成。
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