Fukuoka H, Takeda M, Nomura S, Ogawa T, Sakanishi S
Department of Urology, Yokohama Minami Kyosai Hospital.
Hinyokika Kiyo. 1991 May;37(5):541-4.
The patient was a 61-year-old woman with bladder cancer presenting in stage pT3a, N0, M0, T.C.C. (GIII) greater than S.C.C. Following total cystectomy and one course of cisplatin, adriamycin, cyclophosphamide (CAP) as adjuvant chemotherapy, she was started on futraful and uracil (UFT) at a dose of 4 capsules daily and placed on observation. Since she complained of olfactory anesthesia at 2 months of treatment, the dosage of UFT was reduced to 2 capsules daily and the drug was withdrawn after another 2 months of treatment. With the detection of lung metastases one month later UFT was resumed at a dose of 2 capsules daily. At 4 months of resumed treatment the foci of metastasis completely disappeared. She has since shown a complete remission by small dosage of UFT (2 capsules daily) for 12 months or more.
该患者为一名61岁的膀胱癌女性，呈现pT3a、N0、M0期，移行细胞癌（GIII级），高于鳞状细胞癌。在进行全膀胱切除术及一个疗程的顺铂、阿霉素、环磷酰胺（CAP）辅助化疗后，开始给予氟尿嘧啶替加氟片（UFT），剂量为每日4粒，并进行观察。由于在治疗2个月时她抱怨嗅觉减退，UFT剂量减至每日2粒，在继续治疗2个月后停药。1个月后检测到肺转移，UFT以每日2粒的剂量恢复使用。在恢复治疗4个月时，转移灶完全消失。此后，她通过小剂量UFT（每日2粒）持续12个月或更长时间实现了完全缓解。
