Peet Malcolm
Swallownest Court Hospital, Sheffield, Great Britain.
Isr J Psychiatry Relat Sci. 2008;45(1):19-25.
Most studies have shown reduced levels of polyunsaturated fatty acids, particularly docosahexaenoic acid and arachidonic acid, in the cell membranes of red blood cells from schizophrenic patients. This has led to research interest in the possible therapeutic benefits of omega-3 fatty acids in schizophrenia. There is evidence from double-blind placebo-controlled trials that omega-3 fatty acids might prevent conversion from a prodromal state into first episode psychosis, and reduce the antipsychotic drug requirement in first episode patients. Results in chronic and acutely relapsing schizophrenia have been mixed. The problems associated with single nutrient studies are discussed. Nutrients are normally ingested in complex combinations, and they interact with each other in their normal metabolic and physiological functions. It is likely that optimal nutritional treatment will involve complex combinations of nutrients, preferably as part of a healthy balanced diet rather than by using supplements. However, such approaches have been little evaluated in mental health..
大多数研究表明，精神分裂症患者红细胞细胞膜中的多不饱和脂肪酸水平降低，尤其是二十二碳六烯酸和花生四烯酸。这引发了对ω-3脂肪酸治疗精神分裂症潜在益处的研究兴趣。双盲安慰剂对照试验的证据表明，ω-3脂肪酸可能预防前驱状态转化为首次发作的精神病，并减少首次发作患者对抗精神病药物的需求。慢性和急性复发型精神分裂症的研究结果不一。文中讨论了单一营养素研究存在的问题。营养素通常以复杂的组合形式摄入，它们在正常代谢和生理功能中相互作用。最佳营养治疗可能涉及营养素的复杂组合，最好作为健康均衡饮食的一部分，而不是通过使用补充剂。然而，这种方法在心理健康方面的评估很少。
