Inada O, Yumoto T, Furuse K, Tanaka T
Acta Pathol Jpn. 1976 Jul;26(4):491-501. doi: 10.1111/j.1440-1827.1976.tb00506.x.
Five cases of malignant fibrous histiocytoma originating in the femur and tibia, sometimes with local recurrences, are reported. Histological and clinical characteristics of this lesion were similar to those in soft tissues with the same disease. The present histiocytomas were observed by electron microscopy and shown to consist of 5 types of neoplastic cells which were regarded as undifferentiated cells, histiocyte-like cells, which were predominating, fibroblast-like cells, multinucleated giant cells and xanthomatous cells. These findings led us to confirm the existence of malignant fibrous histiocytoma originating in bone as well as in soft tissues.
报告了5例起源于股骨和胫骨的恶性纤维组织细胞瘤，这些病例有时会出现局部复发。该病变的组织学和临床特征与软组织中相同疾病的特征相似。通过电子显微镜观察了目前的组织细胞瘤，结果显示其由5种肿瘤细胞组成，这些细胞被认为是未分化细胞、占主导地位的组织细胞样细胞、成纤维细胞样细胞、多核巨细胞和黄色瘤细胞。这些发现使我们确认了起源于骨以及软组织的恶性纤维组织细胞瘤的存在。
