Kamiya Yuto, Miyazono Kohei, Miyazawa Keiji
Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, Japan.
FEBS Lett. 2008 Jul 23;582(17):2496-500. doi: 10.1016/j.febslet.2008.05.052. Epub 2008 Jun 25.
In mammals, two inhibitory Smads (I-Smads), Smad6 and Smad7, play pivotal roles in negative regulation of TGF-beta family signaling. Smad7 ubiquitously inhibits TGF-beta family signaling, whereas Smad6 inhibits signaling from the ALK-3/6 subfamily in preference to that from the ALK-1/2 and ALK-4/5/7 subfamilies of TGF-beta family type I receptors. In Drosophila, only one I-Smad, Dad, has been identified. Here we examined inhibitory effects of Dad on type I receptors in Drosophila. Dad inhibited Saxophone (ALK-1/2 orthologue) and Thickveins (ALK-3/6 orthologue) but not Baboon (ALK-4/5/7 orthologue). The differential modes of action of I-Smads in mammals and Drosophila are discussed.
在哺乳动物中，两种抑制性Smad蛋白（I-Smads），即Smad6和Smad7，在TGF-β家族信号的负调控中发挥着关键作用。Smad7普遍抑制TGF-β家族信号，而Smad6优先抑制来自TGF-β家族I型受体的ALK-3/6亚家族的信号，而非来自ALK-1/2和ALK-4/5/7亚家族的信号。在果蝇中，仅鉴定出一种I-Smad蛋白，即Dad。在此，我们研究了Dad对果蝇I型受体的抑制作用。Dad抑制萨克斯管蛋白（ALK-1/2的同源物）和粗脉蛋白（ALK-3/6的同源物），但不抑制狒狒蛋白（ALK-4/5/7的同源物）。文中讨论了I-Smads在哺乳动物和果蝇中的不同作用模式。
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