Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455.
Cold Spring Harb Perspect Biol. 2017 Sep 1;9(9):a022152. doi: 10.1101/cshperspect.a022152.
The transforming growth factor β (TGF-β) family signaling pathway is conserved and ubiquitous in animals. In , fewer representatives of each signaling component are present compared with vertebrates, simplifying mechanistic study of the pathway. Although there are fewer family members, the TGF-β family pathway still regulates multiple and diverse functions in In this review, we focus our attention on several of the classic and best-studied functions for TGF-β family signaling in regulating developmental processes such as embryonic and imaginal disc patterning, but we also describe several recently discovered roles in regulating hormonal, physiological, neuronal, innate immunity, and tissue homeostatic processes.
转化生长因子β（TGF-β）家族信号通路在动物中是保守且普遍存在的。在 中，与脊椎动物相比，每种信号成分的代表较少，这简化了该通路的机制研究。尽管家族成员较少，但 TGF-β 家族通路仍在 中调节多种不同的功能。在这篇综述中，我们重点关注 TGF-β 家族信号在调节 发育过程中的几个经典和研究最多的功能，如胚胎和体节盘的模式形成，但我们也描述了几个最近发现的在调节激素、生理、神经元、先天免疫和组织稳态过程中的作用。
