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肾脏损伤与修复中的免疫系统:两头烧蜡烛?

Immune system in renal injury and repair: burning the candle from both ends?

作者信息

Goligorsky Michael S

机构信息

Renal Research Institute and Division of Nephrology, Department of Medicine and Pharmacology, New York Medical College, Valhalla, NY 10595, United States.

出版信息

Pharmacol Res. 2008 Aug;58(2):122-8. doi: 10.1016/j.phrs.2008.05.011. Epub 2008 Jun 8.

DOI:10.1016/j.phrs.2008.05.011
PMID:18588980
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2755216/
Abstract

This brief overview is focused on the inherent duality of immune responses: on the one hand they may induce inflammation and precipitate injury, on the other, a number of examples of participation in organ and tissue repair are growing. These processes will be reviewed from the nephrological stand-point. Specifically, the role of different leukocyte subsets, innate immunity, nitric oxide production, and stem cells, among others, are presented.

摘要

本简要概述聚焦于免疫反应的内在双重性

一方面,它们可能引发炎症并促成损伤;另一方面,参与器官和组织修复的例子也越来越多。将从肾脏病学角度对这些过程进行综述。具体而言,将介绍不同白细胞亚群、固有免疫、一氧化氮生成以及干细胞等的作用。

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Immune system in renal injury and repair: burning the candle from both ends?肾脏损伤与修复中的免疫系统:两头烧蜡烛?
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Danger-Associated Molecular Patterns Derived From the Extracellular Matrix Provide Temporal Control of Innate Immunity.源自细胞外基质的危险相关分子模式为先天免疫提供了时间控制。
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本文引用的文献

1
Kidney-derived mesenchymal stem cells contribute to vasculogenesis, angiogenesis and endothelial repair.肾源性间充质干细胞有助于血管发生、血管生成和内皮修复。
Kidney Int. 2008 Oct;74(7):879-89. doi: 10.1038/ki.2008.304. Epub 2008 Jul 2.
2
TLR4 links podocytes with the innate immune system to mediate glomerular injury.Toll样受体4(TLR4)将足细胞与固有免疫系统相连,介导肾小球损伤。
J Am Soc Nephrol. 2008 Apr;19(4):704-13. doi: 10.1681/ASN.2007040395. Epub 2008 Feb 6.
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Lipid mediators of autophagy in stress-induced premature senescence of endothelial cells.自噬的脂质介质在应激诱导的内皮细胞早衰中的作用
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Hematopoietic prostaglandin D2 synthase controls the onset and resolution of acute inflammation through PGD2 and 15-deoxyDelta12 14 PGJ2.造血前列腺素D2合酶通过前列腺素D2和15-脱氧-Δ12,14-前列腺素J2控制急性炎症的发生和消退。
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5
The inflammasome: a danger sensing complex triggering innate immunity.炎性小体:一种触发固有免疫的危险感应复合体。
Curr Opin Immunol. 2007 Dec;19(6):615-22. doi: 10.1016/j.coi.2007.09.002. Epub 2007 Oct 30.
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Leukocytes in glomerular injury.肾小球损伤中的白细胞。
Semin Immunopathol. 2007 Nov;29(4):355-74. doi: 10.1007/s00281-007-0097-9. Epub 2007 Oct 16.
7
TLR4 activation mediates kidney ischemia/reperfusion injury.Toll样受体4(TLR4)激活介导肾脏缺血/再灌注损伤。
J Clin Invest. 2007 Oct;117(10):2847-59. doi: 10.1172/JCI31008.
8
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration.细胞内低钾浓度会触发NALP3炎性小体的激活。
Cell Death Differ. 2007 Sep;14(9):1583-9. doi: 10.1038/sj.cdd.4402195. Epub 2007 Jun 29.
9
Resolvin E1 and protectin D1 activate inflammation-resolution programmes.消退素E1和保护素D1激活炎症消退程序。
Nature. 2007 Jun 14;447(7146):869-74. doi: 10.1038/nature05877.
10
Inflammatory cells in renal injury and repair.肾损伤与修复中的炎性细胞
Semin Nephrol. 2007 May;27(3):250-9. doi: 10.1016/j.semnephrol.2007.02.001.