Maugeri N, Rovere-Querini P, Baldini M, Sabbadini M G, Manfredi A A
H. San Raffaele Scientific Institute and Università Vita-Salute San Raffaele, via Olgettina, Milano, Italy.
Clin Exp Immunol. 2009 Jun;156(3):395-404. doi: 10.1111/j.1365-2249.2009.03921.x. Epub 2009 Mar 20.
Vessel walls are the primary inflammatory sites in systemic vasculitides. In most cases the initiating event is unknown, and a self-sustaining circuit attracts and activates inflammatory leucocytes in the wall of vessels of various size and anatomical characteristics. Recent studies have revealed homeostatic roles of vascular inflammation and have identified the action of humoral innate immunity, in particular injury-associated signals and acute phase proteins, on the activation of circulating leucocytes, platelets and endothelial cells. These advances have provided clues to the molecular mechanisms underlying the vicious circle that maintains and amplifies vessel and tissue injury.
血管壁是系统性血管炎的主要炎症部位。在大多数情况下，引发事件尚不清楚，一个自我维持的循环会吸引并激活不同大小和解剖特征血管壁中的炎性白细胞。最近的研究揭示了血管炎症的稳态作用，并确定了体液固有免疫的作用，特别是损伤相关信号和急性期蛋白对循环白细胞、血小板和内皮细胞激活的作用。这些进展为维持和放大血管及组织损伤的恶性循环背后的分子机制提供了线索。
