胰岛肿瘤

Tumors of the islets of Langerhans.

作者信息

Zollinger R M, Mazzaferri E L

出版信息

Adv Surg. 1976;10:137-76.

Abstract

The islet cell tumors of the pancreas are now known to produce a variety of polypeptides in addition to insulin. These include glucagon, serotonin, corticotropin, melanocyte-stimulating hormone, gastrin and a secretinlike hormone that may be VIP or a combination of such polypeptides. The development and wide availability of the newer immunoassays for the various recognized hormones as well as candidate hormones of the gut will simplify the diagnosis of these challenging tumors, which up until this time have produced symptoms that were bizarre and often fatal to the patient.

摘要

现已知道，胰腺胰岛细胞瘤除了产生胰岛素外，还能产生多种多肽。这些多肽包括胰高血糖素、血清素、促肾上腺皮质激素、促黑素、胃泌素以及一种类似促胰液素的激素，后者可能是血管活性肠肽或这些多肽的某种组合。针对各种已确认的激素以及肠道候选激素的新型免疫测定法的开发及其广泛应用，将简化这些具有挑战性的肿瘤的诊断，在此之前，这些肿瘤所产生的症状很怪异，且往往对患者致命。