西地那非对患有性高潮功能障碍的绝经后女性阴蒂血流及性反应的影响。
Effect of sildenafil on clitoral blood flow and sexual response in postmenopausal women with orgasmic dysfunction.
作者信息
Cavalcanti Ana L, Bagnoli Vicente R, Fonseca Angela M, Pastore Roberto A, Cardoso Eduardo B, Paixão Jucilene S, Soares José M, Saad Fabrício, Baracat Edmund C
机构信息
Department of Obstetrics and Gynecology, University of São Paulo, Brazil.
出版信息
Int J Gynaecol Obstet. 2008 Aug;102(2):115-9. doi: 10.1016/j.ijgo.2008.03.020. Epub 2008 Jun 26.
OBJECTIVE
To analyze the effects of sildenafil citrate on clitoral blood flow and sexual response in postmenopausal women with orgasmic dysfunction.
METHOD
In this randomized, double-blind, placebo-controlled trial 22 women received a 50-mg dose of sildenafil (n=11) or placebo (n=11) daily for 15 days. The Golombok Rust Inventory of Sexual Satisfaction (GRISS) was used for subjective evaluation of the sexual-response cycle. Clitoral blood flow was measured by color and pulse Doppler at baseline, after 1 hour of taking the first dose, and after 15 days of treatment.
RESULTS
Blood flow was significantly more improved in the sildenafil than in the placebo group (P<0.05), and a positive correlation between Doppler values and GRISS scores was noted in the sildenafil group after only 15 days of treatment.
CONCLUSION
Sildenafil may improve clitoral blood flow and increase the GRISS scores in postmenopausal women with orgasmic dysfunction.
目的
分析枸橼酸西地那非对患有性高潮功能障碍的绝经后女性阴蒂血流量及性反应的影响。
方法
在这项随机、双盲、安慰剂对照试验中，22名女性每天接受50毫克西地那非（n = 11）或安慰剂（n = 11）治疗，为期15天。使用戈洛姆贝克-拉斯特性满意度量表（GRISS）对性反应周期进行主观评估。在基线、服用首剂1小时后以及治疗15天后，通过彩色和脉冲多普勒测量阴蒂血流量。
结果
西地那非组的血流量改善程度显著高于安慰剂组（P<0.05），且在治疗仅15天后，西地那非组的多普勒值与GRISS评分之间存在正相关。
结论
西地那非可能改善患有性高潮功能障碍的绝经后女性的阴蒂血流量并提高GRISS评分。
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