沙棘提取物与枸橼酸西地那非治疗女性性高潮障碍的比较：一项随机临床试验。
Comparison of Elaeagnus angustifolia Extract and Sildenafil Citrate on Female Orgasmic Disorders: A Randomized Clinical Trial.
作者信息
Akbarzadeh Marzieh, Zeinalzadeh Sanaz, Zolghadri Jaleh, Mohagheghzadeh Abdolali, Faridi Pouya, Sayadi Mehrab
机构信息
Community Based Psychiatric Care Research Center, Department of Midwifery, Fatemeh (P.B.U.H) School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
J Reprod Infertil. 2014 Oct;15(4):190-8.
BACKGROUND
Orgasmic disorder can create a feeling of deprivation and failure and provide mental problems, incompatibility and marital discord. This study aimed to compare the effects of Elaeagnus angustifolia flower extract and sildenafil citrate on female orgasmic disorder in women in 2013.
METHODS
In this randomized clinical trial, 125 women between 18-40 years old who suffered from orgasmic disorder were divided into three E. angustifolia, sildenafil citrate and control groups. The data were gathered using Female Sexual Function Index and through measurement of TSH and prolactin. The first intervention group had to consume 4.5 gr E. angustifolia extract in two divided doses for 35 days and the second one had to use 50 mg sildenafil citrate tablets for 4 weeks one hour before their sexual relationship. However, the control group had to consume the placebo. The data were analyzed using paired t-test, one-way ANOVA, and Bonferroni posthoc test and p<0.05 was considered significant.
RESULTS
The frequency of orgasmic disorder before the intervention was 41.5%, 40.5%, and 57.1% in E. angustifolia, sildenafil citrate, and control groups, respectively (p=0.23). However, these measures were respectively 29.3%, 16.7%, and 50% after the intervention (p=0.004). A significant difference between the two groups regarding sexual satisfaction after the intervention (p=0.003) compared to the beginning of the study (p=0.356). Besides, the highest reduction of changes after the intervention (58.82%) was observed in the sildenafil citrate group.
CONCLUSION
Both E. angustifolia extract and sildenafil citrate were effective in reduction of the frequency of orgasmic disorder in women.
背景
性高潮障碍会产生剥夺感和失败感，并引发心理问题、性不和谐及婚姻不和。本研究旨在比较2013年沙枣花提取物和枸橼酸西地那非对女性性高潮障碍的影响。
方法
在这项随机临床试验中，125名年龄在18至40岁之间患有性高潮障碍的女性被分为沙枣花组、枸橼酸西地那非组和对照组。数据通过女性性功能指数以及促甲状腺激素和催乳素的测量来收集。第一干预组需分两次服用4.5克沙枣花提取物，持续35天，第二干预组需在每次性行为前1小时服用50毫克枸橼酸西地那非片，持续4周。然而，对照组需服用安慰剂。数据采用配对t检验、单因素方差分析和Bonferroni事后检验进行分析，p<0.05被认为具有统计学意义。
结果
干预前，沙枣花组、枸橼酸西地那非组和对照组的性高潮障碍发生率分别为41.5%、40.5%和57.1%（p=0.23）。然而，干预后这些比例分别为29.3%、16.7%和50%（p=0.004）。与研究开始时（p=0.356）相比，干预后两组在性满意度方面存在显著差异（p=0.003）。此外，干预后变化减少最多的是枸橼酸西地那非组（58.82%）。
结论
沙枣花提取物和枸橼酸西地那非均能有效降低女性性高潮障碍的发生率。
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