Britcher Leanne, Barnes Timothy J, Griesser Hans J, Prestidge Clive A
Ian Wark Research Institute, Special Research Centre for Particle and Material Interfaces, University of South Australia, Mawson Lakes Blvd, Mawson Lakes, South Australia, Australia 5095.
Langmuir. 2008 Aug 5;24(15):7625-7. doi: 10.1021/la801619v. Epub 2008 Jul 1.
Porous silicon has received considerable interest in recent years in a range of biomedical applications, with its performance determined by surface chemistry. In this work, we investigate the PEGylation of porous silicon wafers using click chemistry. The porous silicon wafer surface chemistry was monitored at each stage of the reaction via photoacoustic Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy, whereas sessile drop contact angle and model protein adsorption measurements were used to characterize the final PEGylated surface. This work highlights the simplicity of click-chemistry-based functionalization in tailoring the porous silicon surface chemistry and controlling protein-porous silicon interactions.
近年来，多孔硅在一系列生物医学应用中受到了广泛关注，其性能由表面化学决定。在这项工作中，我们使用点击化学研究了多孔硅晶片的聚乙二醇化。通过光声傅里叶变换红外光谱和X射线光电子能谱在反应的每个阶段监测多孔硅晶片的表面化学，而使用静滴接触角和模型蛋白吸附测量来表征最终的聚乙二醇化表面。这项工作突出了基于点击化学的功能化在定制多孔硅表面化学和控制蛋白质 - 多孔硅相互作用方面的简便性。
