Ericsson C H, Svartengren M, Mossberg B, Pedersen N, Camner P
Department of Pulmonary Medicine, Södersjukhuset, Stockholm, Sweden.
Ann Allergy. 1991 Jul;67(1):53-9.
Bronchial reactivity was studied twice in eight monozygotic twin pairs discordant for allergic rhinitis with pollen hypersensitivity, during the winter season (all eight pairs) and during the pollen season (seven pairs). On both occasions, the allergic twins showed significantly higher reactivity than their nonallergic siblings. The results indicate that moderate allergic rhinitis is associated with increased bronchial reactivity. This increased reactivity is an acquired trait; however, bronchial reactivity is not constantly increased in pollen rhinitis and may be normal even during the pollen season. The symptoms of allergic rhinitis usually started in childhood before the separation of the siblings. We could not demonstrate any major differences in exposure to allergens or airway irritants between the siblings. The allergic twins tended to have lower birth weight and insufficient weight increase just after birth.
在冬季（全部八对）和花粉季节（七对），对八对患过敏性鼻炎且对花粉过敏的单卵双胞胎进行了两次支气管反应性研究，其中一对双胞胎患有过敏性鼻炎，另一对则没有。在这两种情况下，患过敏症的双胞胎的反应性均显著高于其未患过敏症的同胞。结果表明，中度过敏性鼻炎与支气管反应性增加有关。这种增加的反应性是一种后天获得的特征；然而，花粉性鼻炎患者的支气管反应性并非持续增加，甚至在花粉季节也可能正常。过敏性鼻炎的症状通常在同胞分离前的儿童期就已开始。我们未能证明同胞之间在接触过敏原或气道刺激物方面存在任何重大差异。患过敏症的双胞胎出生体重往往较低，出生后体重增加不足。
