Kulstrunk M, Honegger U, Wüthrich B, Bühlmann A A
Schweiz Med Wochenschr. 1984 Sep 29;114(39):1331-5.
Nonspecific bronchial reactivity was investigated during and out of the pollen season in 28 pollen-allergic asthmatics and 25 hay fever patients without bronchial asthma. The degree of the reactivity was measured by the decrease of inspiratory specific airway conductance (sGI) after voluntary hyperventilation. Before hyperventilation the mean values for the sGI in both groups of patients were within the low normal range and revealed no seasonal fluctuations. During the pollen season 26 (93%) asthmatics and 14 (56%) hay fever patients showed bronchial hyperreactivity. Out of season 22 (79%) asthmatics and only 8 (32%) hay fever patients were hyperreactive. Thus, in the absence of the relevant allergens, most of the pollen sensitive asthmatics showed a significant increase in unspecific bronchial reactivity which was somewhat higher during the pollen season. The seasonal increase of bronchial reactivity in hay fever patients suggests a relationship with pollen asthma. 12 pollen-allergic asthmatics, who were examined again in the next pollen season after one period of preseasonal specific hyposensitization with pollen extracts, displayed a significant decrease in nonspecific bronchial reactivity.
在花粉季节期间及非花粉季节，对28名花粉过敏的哮喘患者和25名无支气管哮喘的花粉症患者的非特异性支气管反应性进行了研究。反应程度通过自主过度通气后吸气特异性气道传导率（sGI）的降低来测量。在过度通气前，两组患者的sGI平均值均在正常低限范围内，且未显示出季节性波动。在花粉季节，26名（93%）哮喘患者和14名（56%）花粉症患者出现支气管高反应性。在非花粉季节，22名（79%）哮喘患者和仅8名（32%）花粉症患者有高反应性。因此，在没有相关变应原的情况下，大多数花粉敏感的哮喘患者显示出非特异性支气管反应性显著增加，且在花粉季节增加幅度略高。花粉症患者支气管反应性的季节性增加提示与花粉性哮喘有关。12名花粉过敏的哮喘患者，在经过一个花粉季节前用花粉提取物进行特异性减敏治疗的疗程后，在下一个花粉季节再次接受检查时，其非特异性支气管反应性显著降低。
