Xie Wen, Ted Brown W, Denman Robert B
Department of Molecular Biology, Laboratory of Biochemical Molecular Neurobiology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA.
Biochem Biophys Res Commun. 2008 Sep 5;373(4):462-6. doi: 10.1016/j.bbrc.2008.06.075. Epub 2008 Jun 30.
There are several classes of small non-protein-coding RNA (npcRNA) that play important roles in cellular metabolism including mRNA decoding, RNA processing and mRNA stability. Indeed, altered expression of some of these npcRNAs has been associated with cancer, neurodegenerative diseases such as Alzheimer's disease, as well as various types of mental retardation and psychiatric disorders. The basis of this correlation is currently not understood. However, recent studies have begun to shed light on one of the mechanism(s) by which these RNAs exert their effects, namely, translational control. These data provide hope that rational treatments for these varied disorders may be in sight. Here, we review this new body of work.
有几类小的非蛋白质编码RNA（npcRNA）在细胞代谢中发挥重要作用，包括mRNA解码、RNA加工和mRNA稳定性。事实上，其中一些npcRNA的表达改变与癌症、神经退行性疾病如阿尔茨海默病以及各种类型的智力迟钝和精神障碍有关。目前尚不清楚这种相关性的基础。然而，最近的研究已经开始揭示这些RNA发挥作用的一种机制，即翻译控制。这些数据为有望对这些不同疾病进行合理治疗带来了希望。在此，我们综述这一领域的新研究成果。
