Kompagne Hajnalka, Bárdos György, Szénási Gábor, Gacsályi István, Hársing László G, Lévay György
Department of Preclinical Research, EGIS Pharmaceuticals Plc., Budapest, Hungary.
Behav Brain Res. 2008 Nov 21;193(2):311-4. doi: 10.1016/j.bbr.2008.06.008. Epub 2008 Jun 11.
A 3-week chronic mild stress (CMS) protocol decreased sucrose preference of rats and increased immobility in the forced swim test. It also induced social avoidance and increased grooming, but acted as if reducing anxiety in the plus-maze. Sucrose preference and social avoidance, but not other measures of the behaviour, showed significant correlation. We conclude that CMS-induced depression-like behaviour is associated with social avoidance, a seemingly anxiety-related measure, but not with other anxiety-like traits in rats.
为期3周的慢性轻度应激（CMS）方案降低了大鼠的蔗糖偏好，并增加了强迫游泳试验中的不动时间。它还诱发了社交回避并增加了梳理行为，但在十字迷宫试验中却表现出似乎能减轻焦虑的作用。蔗糖偏好和社交回避与行为的其他指标不同，显示出显著相关性。我们得出结论，CMS诱导的抑郁样行为与社交回避有关，社交回避是一种看似与焦虑相关的指标，但与大鼠的其他焦虑样特征无关。
