Marić D, Janković B D, Veljić J
Immunology Research Center, Belgrade, Yugoslavia.
Ann N Y Acad Sci. 1991;621:148-58. doi: 10.1111/j.1749-6632.1991.tb16976.x.
In this study we evaluated the immunorestorative activity of prothymosin-alpha (ProT-alpha) in senescence. Aged rats were repeatedly injected with ProT-alpha after antigen challenge. Both humoral and cell-mediated immune reactions were tested. The results show that ProT-alpha exerted a marked immunopotentiating effect in aged rats. Moreover, ProT-alpha induced enhancement of PFC response, and skin hypersensitivity reactions were more pronounced in senescent rats than in young adult controls. ProT-alpha treatment increased thymus and spleen weights in aged rats, and induced qualitative and quantitative improvements of the cellular make-up of the thymus and thymus-dependent areas of the spleen. The results imply that "restoring" thymus endocrine function by exogenous administration of ProT-alpha may improve immune system homeostasis in senescence.
在本研究中，我们评估了胸腺素α原（ProT-α）在衰老过程中的免疫恢复活性。对抗抗原攻击后的老年大鼠反复注射ProT-α。对体液免疫和细胞介导的免疫反应均进行了检测。结果表明，ProT-α对老年大鼠具有显著的免疫增强作用。此外，ProT-α诱导了PFC反应增强，并且衰老大鼠的皮肤超敏反应比年轻成年对照更明显。ProT-α治疗增加了老年大鼠的胸腺和脾脏重量，并诱导了胸腺和脾脏中胸腺依赖区细胞组成的定性和定量改善。结果表明，通过外源性给予ProT-α“恢复”胸腺内分泌功能可能改善衰老过程中的免疫系统稳态。
