Hocherman S, Alexandrovsky L, Badarny S, Honigman S
Faculty of Medicine, Technion, Israel Institute of Technology, POB 9649, Haifa, Israel; Eve Topf and USA National Parkinson Foundation Centers for Neurodegenerative Diseases, Haifa, Israel.
Parkinsonism Relat Disord. 1998 Oct;4(3):129-36. doi: 10.1016/s1353-8020(98)00034-0.
The visuo-motor coordination of 26 stable, treated, Parkinson's disease (PD) patients with average Hoehn and Yahr rating of 1.75+/-0.6, was assessed by use of several tracing and tracking tests before and 30min after ingestion of the mid-day levodopa (L-DOPA) dose. Significant improvement was found in all aspects of visuo-motor coordination 30min after drug intake. This included the ability to control the direction and velocity of hand-movement, and the capacity to persist in tracking. A subgroup of 12 patients was tested 30min and 1h after L-DOPA intake. A continuing (but small) improvement in directional and velocity control could still be seen an hour after drug intake, while tracking persistence remained unchanged with respect to the preceding test. We conclude that changes in executional capabilities can be documented in "stable" PD patients, consequent to L-DOPA intake, when high-level skills, such as visuo-motor coordination, are tested.
对26名病情稳定、接受过治疗的帕金森病（PD）患者进行了视觉运动协调性评估，这些患者的Hoehn和Yahr平均评分为1.75±0.6。在摄入中午剂量的左旋多巴（L-DOPA）之前和之后30分钟，通过多项描迹和跟踪测试进行评估。服药后30分钟，视觉运动协调性的各个方面均有显著改善。这包括控制手部运动方向和速度的能力，以及持续跟踪的能力。对12名患者组成的亚组在摄入L-DOPA后30分钟和1小时进行了测试。服药1小时后，方向和速度控制方面仍有持续（但较小）的改善，而跟踪持续性与前一次测试相比保持不变。我们得出结论，当测试诸如视觉运动协调性等高阶技能时，摄入L-DOPA后，“病情稳定”的PD患者的执行能力会发生变化，这一点可以得到证明。
