Jansson Y, Eriksson B, Johnels B
Department of Neurology, Göteborg University, Göteborg, Sweden.
Parkinsonism Relat Disord. 1998 Dec;4(4):201-6. doi: 10.1016/s1353-8020(98)00036-4.
In a crossover study we compared the single dose effect of 200mg levodopa (plus decarboxylase inhibitor) in the form of Madopar with that of Madopar Dispersible on the motor performance of eight patients with Parkinson's disease, after 12h without their ordinary anti-parkinsonian medication and food intake. Objective recording of their performance was done with an opto-electronic camera and automatic computerised treatment of the movement data and with scoring according to the United Parkinson's Disease Rating Scale. We conclude that Madopar Dispersible has a much faster and more constant onset of action than the standard preparation (25 vs 46min.). The effect duration and the effects on motor performance were otherwise the same.
在一项交叉研究中，我们比较了200毫克左旋多巴（加脱羧酶抑制剂）以美多芭形式与美多芭分散片对8例帕金森病患者运动功能的单剂量效应。这些患者在停用常规抗帕金森病药物并禁食12小时后接受测试。通过光电摄像机客观记录其运动表现，并对运动数据进行自动计算机处理，同时根据统一帕金森病评定量表进行评分。我们得出结论，美多芭分散片的起效速度比标准制剂快得多且更稳定（分别为25分钟和46分钟）。而作用持续时间以及对运动功能的影响在其他方面是相同的。
