基于同源性的蛋白质功能注释。

Protein functional annotation by homology.

作者信息

Mazumder Raja, Vasudevan Sona, Nikolskaya Anastasia N

机构信息

Protein Information Resource, Georgetown University Medical Center, Washington, DC, USA.

出版信息

Methods Mol Biol. 2008;484:465-90. doi: 10.1007/978-1-59745-398-1_28.

DOI:10.1007/978-1-59745-398-1_28

PMID:18592196

Abstract

Genome sequencing projects have resulted in a rapid accumulation of predicted protein sequences. With experimentally verified information on protein function lagging far behind, computational methods are used for functional annotation of proteins. Here we describe a number of protocols for protein sequence and structure analysis that can be used to infer function of uncharacterized proteins. These protocols rely on publicly available computational resources and tools and can be utilized by anyone with an Internet access.

摘要

基因组测序项目已导致预测蛋白质序列迅速积累。由于关于蛋白质功能的实验验证信息远远滞后，因此使用计算方法对蛋白质进行功能注释。在这里，我们描述了一些蛋白质序列和结构分析的方案，可用于推断未表征蛋白质的功能。这些方案依赖于公开可用的计算资源和工具，任何有互联网接入的人都可以使用。