由3-甲酰基色酮合成喹啉。
Synthesis of quinolines from 3-formylchromone.
作者信息
Plaskon Andrey S, Ryabukhin Sergey V, Volochnyuk Dmitriy M, Gavrilenko Konstantin S, Shivanyuk Alexander N, Tolmachev Andrey A
机构信息
Enamine Ltd., 23 A. Matrosova st., Kyiv 01103, Ukraine.
出版信息
J Org Chem. 2008 Aug 1;73(15):6010-3. doi: 10.1021/jo800950y. Epub 2008 Jul 2.
PMID:18593188
Abstract
A facile and versatile procedure for the synthesis of 3-(2-hydroxybenzoyl)quinolines and 7H-chromeno[3,2-c]quinolin-7-ones was elaborated on the basis of TMSCl-mediated recyclization of 3-formylchromone with various anilines. Limitations and scope of this methodology were established, and a possible mechanism for the heterocyclizations was proposed.
摘要
基于三甲基氯硅烷（TMSCl）介导的3-甲酰基色酮与各种苯胺的环化反应，阐述了一种简便通用的合成3-(2-羟基苯甲酰基)喹啉和7H-色烯并[3,2-c]喹啉-7-酮的方法。确定了该方法的局限性和适用范围，并提出了杂环化的可能机理。
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