Ksiazek Krzysztof, Jörres Achim, Witowski Janusz
Department of Pathophysiology, Poznan University of Medical Sciences, Poznan, Poland.
Rejuvenation Res. 2008 Jun;11(3):681-3. doi: 10.1089/rej.2008.0736.
The incidence of cancers that metastasize to the peritoneum increases with age. Intraperitoneal cancer dissemination depends largely on angiogenesis and interactions with the peritoneal mesothelium. We assessed the proangiogenic potential of human peritoneal mesothelial cells. Conditioned media collected from these cells at senescence stimulated proliferation of endothelial cells to a significantly greater extent compared to media from early-passage cells. The effect was accompanied by a significantly increased release of proangiogenic mediators -- VEGF, CXCL1/GROalpha, CXCL8/IL-8, and CCL2/MCP-1. These results indicate that the senescent mesothelium exhibits increased angiogenic activity, which may contribute to accelerated intraperitoneal cancer progression in the aged.
转移至腹膜的癌症发病率随年龄增长而增加。腹膜内癌症播散很大程度上取决于血管生成以及与腹膜间皮的相互作用。我们评估了人腹膜间皮细胞的促血管生成潜力。与早期传代细胞的培养基相比，从衰老的这些细胞收集的条件培养基能显著刺激内皮细胞增殖。该效应伴随着促血管生成介质——血管内皮生长因子（VEGF）、CXC趋化因子配体1/生长调节致癌基因α（CXCL1/GROα）、CXC趋化因子配体8/白细胞介素-8（CXCL8/IL-8）和C-C趋化因子配体2/单核细胞趋化蛋白-1（CCL2/MCP-1）的释放显著增加。这些结果表明，衰老的间皮表现出增强的血管生成活性，这可能有助于加速老年人腹膜内癌症的进展。
