Piano Amanda, Titorenko Vladimir I
Department of Biology, Concordia University, Montreal, Quebec, Canada.
Aging Dis. 2014 Feb 16;6(1):56-75. doi: 10.14336/AD.2014.0209. eCollection 2015 Feb.
Age is the major risk factor in the incidence of cancer, a hyperplastic disease associated with aging. Here, we discuss the complex interplay between mechanisms underlying aging and cancer as a reciprocal relationship. This relationship progresses with organismal age, follows the history of cell proliferation and senescence, is driven by common or antagonistic causes underlying aging and cancer in an age-dependent fashion, and is maintained via age-related convergent and divergent mechanisms. We summarize our knowledge of these mechanisms, outline the most important unanswered questions and suggest directions for future research.
年龄是癌症发病率的主要风险因素,癌症是一种与衰老相关的增生性疾病。在此,我们将衰老与癌症背后的机制之间复杂的相互作用作为一种相互关系进行讨论。这种关系随着机体年龄的增长而发展,遵循细胞增殖和衰老的历程,以年龄依赖的方式由衰老和癌症背后的共同或拮抗原因驱动,并通过与年龄相关的趋同和趋异机制得以维持。我们总结了对这些机制的认识,概述了最重要的未解决问题,并提出了未来研究的方向。