自体角质形成细胞移植后伤口愈合的数学模型
Mathematical model for wound healing following autologous keratinocyte transplantation.
作者信息
Renner Regina, Teuwen Isabell, Gebhardt Carl, Simon Jan C
机构信息
Department of Dermatology, Venereology and Allergology, University of Leipzig, Medical Center, Leipzig, Germany.
出版信息
Int Wound J. 2008 Jun;5(3):445-52. doi: 10.1111/j.1742-481X.2007.00404.x.
In times of increasing economical pressure on the health care systems, it is important to optimise the outpatient treatment of chronic wounds. Another aim of wound healing research is to discover agents to accelerate healing. Wound healing trajectories or healing velocities can provide information to demonstrate the endpoints for wound healing. A great problem in clinical trials is to specify these parameters. Therefore, we developed a mathematical model for more transparency. In this initial project, we observed 19 wounds to construct the wound healing trajectories after transplantation of autologous keratinocytes, and the results are so encouraging that investigation in this area will continue. The developed mathematical model describes the clinical observed healing process. It was possible to find parameters to distinguish between old and young patients, retrospectively or prospectively calculate the healing rates and to determine exactly the endpoint of healing. Therefore, our model might be very useful in practices or for studies.
在医疗保健系统面临日益增加的经济压力之际，优化慢性伤口的门诊治疗至关重要。伤口愈合研究的另一个目标是发现加速愈合的药物。伤口愈合轨迹或愈合速度可以提供信息以证明伤口愈合的终点。临床试验中的一个大问题是确定这些参数。因此，我们开发了一个数学模型以提高透明度。在这个初始项目中，我们观察了19个伤口，以构建自体角质形成细胞移植后的伤口愈合轨迹，结果非常令人鼓舞，该领域的研究将继续进行。所开发的数学模型描述了临床观察到的愈合过程。可以找到区分老年和年轻患者的参数，回顾性或前瞻性地计算愈合率，并准确确定愈合终点。因此，我们的模型在实践或研究中可能非常有用。
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