Al-Ani Amer N, Samuelsson Bodil, Tidermark Jan, Norling Asa, Ekström Wilhelmina, Cederholm Tommy, Hedström Margareta
Karolinska Institutet, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital Huddinge, SE-141 86 Stockholm, Sweden.
J Bone Joint Surg Am. 2008 Jul;90(7):1436-42. doi: 10.2106/JBJS.G.00890.
The outcome for many patients with a hip fracture remains poor. The aim of the present study was to investigate whether the timing of surgery in such patients could influence the short-term clinical outcome.
We included 850 consecutive patients with a hip fracture who were admitted to the hospital during one year in a prospective study. Three cutoff limits for a comparison of early and late operation were defined. The outcome (the ability to return to independent living, risk for the development of pressure ulcers, length of the hospital stay, and mortality rate) for patients who had an operation within twenty-four, thirty-six, and forty-eight hours was compared with the outcome for those who had an operation at a later time.
Patients who had the operation more than thirty-six and forty-eight hours after admission were less likely to return to independent living within four months (odds ratio, 0.44 and 0.33, respectively), whereas there was no significant difference with use of the twenty-four-hour cutoff limit. The incidence of pressure ulcers in the groups that had the operation later was increased at all three cutoff limits (a delay of more than twenty-four hours, more than thirty-six hours, and more than forty-eight hours) (odds ratio, 2.19, 3.42, and 4.34, respectively). The length of hospitalization was also increased in the groups that had the later operation (median, fourteen compared with eighteen days, fifteen compared with nineteen days, and fifteen compared with twenty-one days, respectively) (p < 0.001 for all comparisons). The importance of surgical timing remained significant after adjusting for several possible confounders (p < 0.05).
Early compared with late operative treatment of patients with a hip fracture is associated with an improved ability to return to independent living, a reduced risk for the development of pressure ulcers, and a shortened hospital stay.
许多髋部骨折患者的预后仍然很差。本研究的目的是调查此类患者的手术时机是否会影响短期临床结局。
我们纳入了一项前瞻性研究中连续一年入院的850例髋部骨折患者。定义了三个用于比较早期和晚期手术的截止时间。将在24小时、36小时和48小时内进行手术的患者的结局(恢复独立生活的能力、发生压疮的风险、住院时间和死亡率)与手术时间较晚的患者的结局进行比较。
入院后超过36小时和48小时进行手术的患者在四个月内恢复独立生活的可能性较小(优势比分别为0.44和0.33),而使用24小时截止时间时则无显著差异。在所有三个截止时间(延迟超过24小时、超过36小时和超过48小时)下,手术较晚的组中压疮的发生率均增加(优势比分别为2.19、3.42和4.34)。手术较晚的组的住院时间也增加了(中位数分别为14天与18天、15天与19天、15天与21天)(所有比较的p<0.001)。在调整了几个可能的混杂因素后,手术时机的重要性仍然显著(p<0.05)。
与晚期手术治疗相比,早期手术治疗髋部骨折患者可提高恢复独立生活的能力,降低发生压疮的风险,并缩短住院时间。