Rosa Heitor, Parise Edison Roberto
Unit of Gastroenterology and Hepatology, Federal University of Goias School of Medicine, Rua 126 n. 21, Setor Sul, Goiania, Goias 74093-080, Brazil.
World J Gastroenterol. 2008 Jun 21;14(23):3628-32. doi: 10.3748/wjg.14.3628.
Laminin is a glycoprotein which has an important role in the mechanism of fibrogenesis and is, thus, related to hepatic fibrosis in addition to presenting increased levels in several types of neoplasias. However, its determination is not routinely considered in the study of hepatic fibrosis. In this review, the authors critically comment on the role of this glycoprotein compared to other markers of fibrosis through non-invasive procedures (Fibroscan). They also consider its clinical investigational potential and believe that the continuation of these investigations might contribute to a better understanding of the fibrogenic mechanism, which could in turn either lead to the identification of patients at risk of developing fibrosis non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) or at least be used as an indicator for hepatic biopsy in such patients. Finally, the authors believe that serum laminin determination might contribute to the diagnosis of epithelial tumor metastasis and peritoneal carcinomatosis.
层粘连蛋白是一种糖蛋白，在纤维生成机制中起重要作用，因此，除了在几种类型的肿瘤中水平升高外，还与肝纤维化有关。然而，在肝纤维化研究中，通常不考虑对其进行测定。在这篇综述中，作者通过非侵入性程序（Fibroscan），批判性地评论了这种糖蛋白与其他纤维化标志物相比的作用。他们还考虑了其临床研究潜力，并认为继续这些研究可能有助于更好地理解纤维生成机制，这反过来可能导致识别有发展为非酒精性脂肪性肝病（NAFLD）和非酒精性脂肪性肝炎（NASH）纤维化风险的患者，或者至少用作此类患者肝活检的指标。最后，作者认为血清层粘连蛋白测定可能有助于上皮肿瘤转移和腹膜癌病的诊断。
