Suzuki Seiji, Sasajima Koji, Miyamoto Masayuki, Watanabe Hidehiro, Yokoyama Tadashi, Maruyama Hiroshi, Matsutani Takeshi, Liu Aimin, Hosone Masaru, Maeda Shotaro, Tajiri Takashi
Department of Surgery, Tama-Nagayama Hospital, Nippon Medical School, 1-7-1 Nagayama, Tama, Tokyo 206-8512, Japan.
World J Gastroenterol. 2008 Jun 21;14(23):3763-7. doi: 10.3748/wjg.14.3763.
A 39-year-old male underwent distal gastrectomy for a high grade gastrointestinal stromal tumor (GIST). Computed tomography (CT) and magnetic resonance imaging (MRI) 107 mo after the operation, revealed a cystic mass (14 cm in diameter) and a solid mass (9 cm in diameter) in the right and left lobes of the liver, respectively. A biopsy specimen of the solid mass showed a liver metastasis of GIST. The patient received imatinib mesylate (IM) treatment, 400 mg/day orally. Following the IM treatment for a period of 35 mo, the patient underwent partial hepatectomy (S4 + S5). The effect of IM on the metastatic lesions was interpreted as pathologic complete response (CR). Pathologically verified cases showing therapeutic efficacy of IM have been rarely reported.
一名39岁男性因高级别胃肠道间质瘤（GIST）接受了远端胃切除术。术后107个月的计算机断层扫描（CT）和磁共振成像（MRI）显示，肝脏右叶有一个囊性肿块（直径14厘米），左叶有一个实性肿块（直径9厘米）。实性肿块的活检标本显示为GIST肝转移。患者接受甲磺酸伊马替尼（IM）治疗，口服400毫克/天。在接受IM治疗35个月后，患者接受了肝部分切除术（S4 + S5）。IM对转移病灶的作用被解释为病理完全缓解（CR）。很少有病理证实显示IM治疗有效的病例报道。
