经甲磺酸伊马替尼治疗后，通过手术切除证实的胃肠道间质瘤肝转移的病理完全缓解。
Pathologic complete response confirmed by surgical resection for liver metastases of gastrointestinal stromal tumor after treatment with imatinib mesylate.
作者信息
Suzuki Seiji, Sasajima Koji, Miyamoto Masayuki, Watanabe Hidehiro, Yokoyama Tadashi, Maruyama Hiroshi, Matsutani Takeshi, Liu Aimin, Hosone Masaru, Maeda Shotaro, Tajiri Takashi
机构信息
Department of Surgery, Tama-Nagayama Hospital, Nippon Medical School, 1-7-1 Nagayama, Tama, Tokyo 206-8512, Japan.
出版信息
World J Gastroenterol. 2008 Jun 21;14(23):3763-7. doi: 10.3748/wjg.14.3763.
A 39-year-old male underwent distal gastrectomy for a high grade gastrointestinal stromal tumor (GIST). Computed tomography (CT) and magnetic resonance imaging (MRI) 107 mo after the operation, revealed a cystic mass (14 cm in diameter) and a solid mass (9 cm in diameter) in the right and left lobes of the liver, respectively. A biopsy specimen of the solid mass showed a liver metastasis of GIST. The patient received imatinib mesylate (IM) treatment, 400 mg/day orally. Following the IM treatment for a period of 35 mo, the patient underwent partial hepatectomy (S4 + S5). The effect of IM on the metastatic lesions was interpreted as pathologic complete response (CR). Pathologically verified cases showing therapeutic efficacy of IM have been rarely reported.
一名39岁男性因高级别胃肠道间质瘤（GIST）接受了远端胃切除术。术后107个月的计算机断层扫描（CT）和磁共振成像（MRI）显示，肝脏右叶有一个囊性肿块（直径14厘米），左叶有一个实性肿块（直径9厘米）。实性肿块的活检标本显示为GIST肝转移。患者接受甲磺酸伊马替尼（IM）治疗，口服400毫克/天。在接受IM治疗35个月后，患者接受了肝部分切除术（S4 + S5）。IM对转移病灶的作用被解释为病理完全缓解（CR）。很少有病理证实显示IM治疗有效的病例报道。
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