7-(2-亚甲基丁酰基)-2,3-二氢苯并恶嗪-[1,4]-3-酮结构的药物调节作用及降血脂活性。
Pharmacomodulation of 7-(2-methylene-butyryl)-2,3-dihydrobenzoxazin-[1,4]-3-one structure and normolipemic activity.
作者信息
Moussavi Z, Depreux P, Lesieur D, Cotelle N, Sauzieres J, Plancke M O, Fruchart J C
机构信息
Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, Lille, France.
出版信息
Farmaco. 1991 Feb;46(2):339-55.
PMID:1859587
Abstract
A series of compounds from 7-(2-methylene butyryl)-2,3-dihydro benzoxazin-[1,4]-3-one was synthesized and evaluated for its lipid lowering action in animal models. Substitutions in positions 2, 4 and 7 were performed. The results of the structure-activity relationships are very difficult to be interpreted. The different modifications tested did not show any improvement in the normolipemic activity.
摘要
合成了一系列源自7-(2-亚甲基丁酰基)-2,3-二氢苯并恶嗪-[1,4]-3-酮的化合物，并在动物模型中评估了其降脂作用。对2、4和7位进行了取代。构效关系的结果很难解释。所测试的不同修饰在正常血脂活性方面未显示出任何改善。
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