Carroll Kecia N, Gebretsadik Tebeb, Griffin Marie R, Wu Pingsheng, Dupont William D, Mitchel Edward F, Enriquez Rachel, Hartert Tina V
Department of Pediatrics, Division of General Pediatrics, Child and Adolescent Health Research Unit, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-8300, USA.
Pediatrics. 2008 Jul;122(1):58-64. doi: 10.1542/peds.2007-2087.
The goals were to estimate the year-round burden of health care visits attributable to bronchiolitis and to identify risk factors for bronchiolitis in term healthy infants.
We conducted a population-based, retrospective cohort study of 103 670 term, non-low birth weight infants enrolled in Tennessee Medicaid in 1995-2003. We monitored infants through the first year of life. Risk factors for bronchiolitis during infancy and rates of inpatient, emergency department, and outpatient visits during the study period were calculated by using claims data.
Over the 9 study years, rates of bronchiolitis visits were 238 outpatient visits per 1000 infant-years, 77 emergency department visits per 1000 infant-years, and 71 hospitalizations per 1000 infant-years. Average annual rates of bronchiolitis visits increased 41%, from 188 visits per 1000 infant-years to 265 visits per 1000 infant-years, from 1996-1997 to 2002-2003. Analysis of the linear trend in 500-g increments demonstrated a negative association between increasing birth weight and bronchiolitis diagnosis. There was a significant negative trend between maternal age and infant bronchiolitis diagnosis. Compared with infants of mothers 20 to 29 years of age, infants of mothers 15 to 19 years of age had a small increase in risk of having a bronchiolitis visit, whereas infants of older mothers (30-39 or 40-44 years of age) were less likely to have a visit.
The disease burden of bronchiolitis is substantial, with increasing rates of all types of visits among term, otherwise-healthy infants enrolled in Tennessee Medicaid between 1995 and 2003. Protective factors in this cohort of term infants included higher birth weight and older maternal age.
本研究旨在评估毛细支气管炎导致的全年医疗就诊负担,并确定足月健康婴儿患毛细支气管炎的风险因素。
我们对1995 - 2003年田纳西州医疗补助计划登记的103670名足月、非低体重婴儿进行了一项基于人群的回顾性队列研究。我们对婴儿进行了为期一年的监测。通过索赔数据计算婴儿期毛细支气管炎的风险因素以及研究期间的住院、急诊和门诊就诊率。
在9年的研究期间,毛细支气管炎的门诊就诊率为每1000婴儿年238次,急诊就诊率为每1000婴儿年77次,住院率为每1000婴儿年71次。从1996 - 1997年到2002 - 2003年,毛细支气管炎的年均就诊率增长了41%,从每1000婴儿年188次增至每1000婴儿年265次。以500克为增量分析线性趋势表明,出生体重增加与毛细支气管炎诊断呈负相关。母亲年龄与婴儿毛细支气管炎诊断之间存在显著的负相关趋势。与20至29岁母亲的婴儿相比,15至19岁母亲的婴儿患毛细支气管炎就诊的风险略有增加,而年龄较大母亲(30 - 39或40 - 44岁)的婴儿就诊可能性较小。
毛细支气管炎的疾病负担较重,1995年至2003年期间,田纳西州医疗补助计划登记的足月、健康婴儿各类就诊率均有所上升。该足月婴儿队列中的保护因素包括较高的出生体重和较大的母亲年龄。