Corrada M M, Brookmeyer R, Berlau D, Paganini-Hill A, Kawas C H
Department of Neurology, University of California Irvine, Irvine, CA 92697-1400, USA.
Neurology. 2008 Jul 29;71(5):337-43. doi: 10.1212/01.wnl.0000310773.65918.cd. Epub 2008 Jul 2.
Although the prevalence of dementia increases with age from ages 65 to 85, whether this increase continues after age 90 is unclear. Most studies reporting on dementia prevalence do not have sufficient participants to estimate prevalence for specific ages and sexes above age 90. Here, we estimate age- and sex-specific prevalence of all-cause dementia in the oldest-old, those aged 90 and older.
Participants are 911 elderly from The 90+ Study, a population-based study of aging and dementia in people aged 90 and above. Dementia was diagnosed using in-person examinations as well as telephone and informant questionnaires.
The overall prevalence of all-cause dementia was higher in women (45%, 95% CI = 41.5-49.0) than men (28%, 95% CI = 21.7-34.2). Among women, prevalence increased with age after age 90, essentially doubling every 5 years. A lower prevalence of dementia was significantly associated with higher education in women but not in men.
In a very large sample of participants aged 90 and older, prevalence of all-cause dementia doubled every 5 years for women but not men.
尽管65岁至85岁之间痴呆症的患病率随年龄增长而上升,但90岁以后这种上升趋势是否持续尚不清楚。大多数关于痴呆症患病率的研究没有足够的参与者来估计90岁以上特定年龄和性别的患病率。在此,我们估计90岁及以上高龄老人全因痴呆症的年龄和性别特异性患病率。
参与者为来自“90+研究”的911名老年人,该研究是一项基于人群的90岁及以上人群衰老与痴呆症研究。痴呆症通过面对面检查以及电话和知情者问卷进行诊断。
全因痴呆症的总体患病率女性(45%,95%置信区间=41.5 - 49.0)高于男性(28%,95%置信区间=21.7 - 34.2)。在女性中,90岁以后患病率随年龄增长而上升,每5年基本翻倍。痴呆症患病率较低与女性的高学历显著相关,但与男性无关。
在一个非常大的90岁及以上参与者样本中,女性全因痴呆症患病率每5年翻倍,而男性则不然。