基于汇总分析的中国农村地区痴呆症患者患病率、全因死亡率和生存状况趋势。
Trends on Prevalence, All-Cause Mortality, and Survival Status of Dementia Patients in Rural China Based on Pooling Analysis.
机构信息
Department of Neurology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University, Xi'an, China.
出版信息
Int J Public Health. 2024 Aug 22;69:1606786. doi: 10.3389/ijph.2024.1606786. eCollection 2024.
OBJECTIVES
No study has reported secular trends in dementia prevalence, all-cause mortality, and survival status in rural China.
METHODS
We established two cohorts (XRRCC1 and XRRCC2) in the same region of China, 17 years apart, to compare dementia prevalence, all-cause mortality, and survival status, and performed regression analysis to identify associated factors.
RESULTS
Dementia prevalence was 3.49% in XRRCC1 and 4.25% in XRRCC2, with XRRCC2 showing a significantly higher prevalence (OR = 1.79, 95%CI: 1.2-2.65). All-cause mortality rates for dementia patients were 62.0% in XRRCC1 and 35.7% in XRRCC2. Mortality in the normal population of XRRCC2 decreased by 66% compared to XRRCC1, mainly due to improved survival rates in women with dementia. Dementia prevalence was positively associated with age >65, spouse-absent status, and stroke, and negatively associated with ≥6 years of education.
CONCLUSION
Dementia prevalence in rural China increased over 17 years, while mortality decreased. Major risk factors include aging, no spouse, and stroke, with higher education offering some protection.
目的
目前尚无研究报告中国农村地区痴呆患病率、全因死亡率和生存状况的长期变化趋势。
方法
我们在同一地区建立了两个队列（XRRCC1 和 XRRCC2），时间相隔 17 年，以比较痴呆患病率、全因死亡率和生存状况，并进行回归分析以确定相关因素。
结果
XRRCC1 中的痴呆患病率为 3.49%，XRRCC2 中的痴呆患病率为 4.25%，XRRCC2 的患病率显著更高（OR=1.79，95%CI：1.2-2.65）。XRRCC1 中痴呆患者的全因死亡率为 62.0%，而 XRRCC2 中为 35.7%。与 XRRCC1 相比，XRRCC2 中痴呆患者的全因死亡率下降了 66%，这主要归因于女性痴呆患者的生存率提高。痴呆患病率与年龄>65 岁、丧偶状态和中风呈正相关，与受教育年限≥6 年呈负相关。
结论
中国农村地区的痴呆患病率在 17 年内有所上升，而死亡率有所下降。主要危险因素包括老龄化、无配偶和中风，而较高的教育水平提供了一定的保护。
Zotero 插件