Sone Toshimasa, Nakaya Naoki, Ohmori Kaori, Shimazu Taichi, Higashiguchi Mizuka, Kakizaki Masako, Kikuchi Nobutaka, Kuriyama Shinichi, Tsuji Ichiro
Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Psychosom Med. 2008 Jul;70(6):709-15. doi: 10.1097/PSY.0b013e31817e7e64. Epub 2008 Jul 2.
To investigate the association between the sense of "life worth living (ikigai)" and the cause-specific mortality risk. The psychological factors play important roles in morbidity and mortality risks. However, the association between the negative psychological factors and the risk of mortality is inconclusive.
The Ohsaki Study, a prospective cohort study, was initiated on 43,391 Japanese adults. To assess if the subjects found a sense of ikigai, they were asked the question, "Do you have ikigai in your life?" We used Cox regression analysis to calculate the hazard ratio of the all-cause and cause-specific mortality according to the sense of ikigai categories.
Over 7 years' follow-up, 3048 of the subjects died. The risk of all-cause mortality was significantly higher among the subjects who did not find a sense of ikigai as compared with that in the subjects who found a sense of ikigai; the multivariate adjusted hazard ratio (95% confidence interval) was 1.5 (1.3-1.7). As for the cause-specific mortality, subjects who did not find a sense of ikigai were significantly associated with an increased risk of cardiovascular disease (1.6; 1.3-2.0) and external cause mortality (1.9; 1.1-3.3), but not of the cancer mortality (1.3; 1.0-1.6).
In this prospective cohort study, subjects who did not find a sense of ikigai were associated with an increased risk of all-cause mortality. The increase in mortality risk was attributable to cardiovascular disease and external causes, but not cancer.
探讨“生活意义（ikigai）”感与特定病因死亡风险之间的关联。心理因素在发病和死亡风险中起着重要作用。然而，负面心理因素与死亡风险之间的关联尚无定论。
大崎研究是一项前瞻性队列研究，对43391名日本成年人进行了调查。为了评估受试者是否找到了生活意义，他们被问到“你生活中有ikigai吗？”我们使用Cox回归分析，根据生活意义类别计算全因和特定病因死亡的风险比。
经过7年的随访，3048名受试者死亡。与找到生活意义的受试者相比，未找到生活意义的受试者全因死亡风险显著更高；多变量调整后的风险比（95%置信区间）为1.5（1.3 - 1.7）。至于特定病因死亡，未找到生活意义的受试者与心血管疾病（1.6；1.3 - 2.0）和外因死亡率（1.9；1.1 - 3.3）风险增加显著相关，但与癌症死亡率（1.3；1.0 - 1.6）无关。
在这项前瞻性队列研究中，未找到生活意义的受试者全因死亡风险增加。死亡风险的增加归因于心血管疾病和外因，但与癌症无关。
