Patsenker Leonid, Tatarets Anatoliy, Kolosova Olga, Obukhova Olena, Povrozin Yevgeniy, Fedyunyayeva Iryna, Yermolenko Inna, Terpetschnig Ewald
State Scientific Institution Institute for Single Crystals of the National Academy of Sciences of Ukraine, 60 Lenin Ave., 61001 Kharkov, Ukraine.
Ann N Y Acad Sci. 2008;1130:179-87. doi: 10.1196/annals.1430.035.
Fluorescence probes and labels have become indispensable tools for clinical diagnostics, high-throughput screening, and other biomedical applications. We have developed several classes of new squaraine-based red and near-infrared (NIR) probes and labels (SETA and Square series), naphthalimide-based fluorescence lifetime dyes (SeTau series), and cyanine- and squaraine-based quenchers (SQ series). This report discusses the spectral and photophysical properties of these new markers. In particular, the red and NIR dyes of the SETA and Square series are extremely bright, with photostabilities that are unmatched by any other dyes in the same spectral region.
荧光探针和标记物已成为临床诊断、高通量筛选及其他生物医学应用中不可或缺的工具。我们已开发出几类新型基于方酸的红色和近红外（NIR）探针及标记物（SETA和Square系列）、基于萘二甲酰亚胺的荧光寿命染料（SeTau系列）以及基于花青和方酸的猝灭剂（SQ系列）。本报告讨论了这些新型标记物的光谱和光物理性质。特别是，SETA和Square系列的红色和近红外染料极其明亮，其光稳定性在同一光谱区域内优于任何其他染料。
