Tvede N, Brynskov J
Laboratory of Medical Immunology TTA, Copenhagen University Hospital, Denmark.
APMIS. 1991 Aug;99(8):759-64. doi: 10.1111/j.1699-0463.1991.tb01256.x.
The functional capacity of biologically active, high-affinity interleukin-2 receptors (IL-2R) was studied by means of interleukin-2 (IL-2) stimulation of blood mononuclear cells (BMC) from 22 patients with inflammatory bowel disease (IBD) and 24 controls. The spontaneous, as well as the IL-2-induced, proliferative responses were significantly decreased in patients with active IBD, whereas the expressions of biologically inactive, low-affinity IL-2R (i.e. TAC antigen or CD25) were significantly increased in the same BMC cultures. In contrast, no significant differences were seen between patients and controls when BMC were stimulated with a nonspecific mitogen (phytohemagglutinin). The results suggest that a downregulation of IL-2 responsiveness may contribute to decreased BMC proliferation in vitro in active IBD.
通过用白细胞介素-2（IL-2）刺激22例炎症性肠病（IBD）患者和24例对照的血液单核细胞（BMC），研究了生物活性高亲和力白细胞介素-2受体（IL-2R）的功能能力。活动期IBD患者的自发增殖反应以及IL-2诱导的增殖反应均显著降低，而在相同的BMC培养物中，生物无活性的低亲和力IL-2R（即TAC抗原或CD25）的表达显著增加。相反，当用非特异性有丝分裂原（植物血凝素）刺激BMC时，患者和对照之间未观察到显著差异。结果表明，IL-2反应性的下调可能导致活动期IBD患者体外BMC增殖减少。
