Martin Stefan F, Jakob Thilo
Allergy Research Group, Department of Dermatology, University Medical Center Freiburg, Freiburg, Germany.
Curr Opin Allergy Clin Immunol. 2008 Aug;8(4):289-93. doi: 10.1097/ACI.0b013e3283088cf9.
To summarize recent findings that highlight the importance of the innate inflammatory immune responses in contact dermatitis and their role for the adaptive T-cell response to contact allergens. Implications for anti-inflammatory therapy based on recent reports are discussed.
Allergic contact dermatitis is studied widely in the mouse model. Recent work has identified an important role of innate pattern recognition receptors and innate immune cells in contact hypersensitivity. The role of skin dendritic cells has been studied with novel approaches for in-vivo depletion. New findings were made in the field of anti-inflammatory therapy either by uncovering new aspects of pathomechanisms or by the use of drugs that target different elements of the inflammatory cascade.
Inflammation is a pivotal element of allergic contact dermatitis. Studies in the mouse contact hypersensitivity model are beginning to shed light on the still largely unknown molecular mechanisms that enable contact allergens such as chemicals, metal ions and plant compounds to initiate the inflammatory innate immune response. This is a prerequisite for the adaptive immune response to occur. The recent progress in research points out the great potential of anti-inflammatory therapy covering a wide range of molecular targets.
总结近期研究结果，强调先天性炎症免疫反应在接触性皮炎中的重要性及其在针对接触性变应原的适应性T细胞反应中的作用。并根据近期报道讨论其对抗炎治疗的意义。
在小鼠模型中对过敏性接触性皮炎进行了广泛研究。近期工作已确定先天性模式识别受体和先天性免疫细胞在接触性超敏反应中的重要作用。采用新的体内清除方法对皮肤树突状细胞的作用进行了研究。在抗炎治疗领域有了新发现，要么是通过揭示发病机制的新方面，要么是通过使用针对炎症级联反应不同成分的药物。
炎症是过敏性接触性皮炎的关键要素。对小鼠接触性超敏反应模型的研究开始揭示出仍然很大程度上未知的分子机制，这些机制使化学物质、金属离子和植物化合物等接触性变应原能够引发炎症性先天性免疫反应。这是适应性免疫反应发生的先决条件。近期的研究进展指出了涵盖广泛分子靶点的抗炎治疗的巨大潜力。
